The data set contained in this archive was developed and used to conduct a study titled 'Exploring Cooperative Transboundary River Management Strategies for the Eastern Nile Basin'. The data set includes three ensembles of hydrologic inputs, each developed from a simulated annealing technique. A baseline ensemble uses statistical properties similar to historical conditions from 1900-2002. A second ensemble increases the interannual standard deviation of all inputs by 15%. A third ensemble increases the long-term persistence of all inputs by increasing the Hurst coefficient by 20%. The data provides inputs for the Eastern Nile RiverWare Model (ENRMv3.3). The study explored cooperative management strategies between the countries of Ethiopia, Sudan and Egypt after the construction of the Grand Ethiopian Renaissance Dam using a multi-objective evolutionary algorithm. This results of this study have been published in Water Resources Research (https://doi.org/10.1029/2017WR022149).